QL47

QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC₅₀ of 7 nM^[1][2][3]. In Vitro:QL47 inhibits protein neosynthesis initiated by both canonical cap-driven and noncanonical initiation strategies, most likely by targeting an early step in translation elongation^[2].
QL47 inhibits autophosphorylation of BTK on Tyr223 in cells with an EC₅₀ of 475 nM, and inhibits phosphorylation of a downstream effector PLCγ2 (Tyr759) with an EC₅₀ of 318 nM. In Ramos cells QL47 induces a G1 cell cycle arrest that is associated with pronounced degradation of BTK protein. QL47 inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations^[3].