Oxolinic acid
CAS No. : 14698-29-4
| Size | Price | Stock |
|---|---|---|
| 500mg | $30 | In-stock |
| 1g | $40 | In-stock |
| 5g | $80 | In-stock |
| 10g | $130 | In-stock |
| 25g | $300 | In-stock |
| 50g | $420 | In-stock |
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| Cat. No. : | HY-B1002 |
| M.Wt: | 261.23 |
| Formula: | C13H11NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Oxolinic acid is an antibiotic against both Gram-negative and Gram-positive bacteria. Oxolinic acid can be used for the research of acute and chronic urinary tract infections. Oxolinic acid is a DNA/RNA synthesis inhibitor. Oxolinic acid acts a dopamine uptake inhibitor and stimulants locomotor effect in mice[1][2][3].
IC50 & Target: Antimicrobial[1]
In Vitro: Oxolinic acid (2-5 ug/mL) inhibits 115 strains of E. coli[1].
Oxolinic acid (0-31 ug/mL) inhibits 94 % of the 44 strains of Proteus mirabilis [1].
Oxolinic acid (>5 ug/mL) inhibits all strains of Strept. Faecalis[1].
Oxolinic acid (>2 ug/mL) causes chromosomal DNA supercoiling to decrease in the two wild-type E. coli K-12 strains tested, DM4100 and NI747[2].
Oxolinic acid reduces chromosomal DNA supercoiling and inhibits RNA synthesis in E. coli[2].
In Vivo: Oxolinic acid (32 mg/kg; i.p.) induces hyperactivity in mice[3].
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