Tipepidine (citrate)
CAS No. : 14698-07-8
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| Cat. No. : | HY-B2185 |
| M.Wt: | 467.56 |
| Formula: | C21H25NO7S2 |
| Purity: | >98 % |
| Solubility: |
Tipepidine citrate is a non-narcotic antitussive agent. Tipepidine citrate reversibly inhibits dopamine D2 receptor-mediated GIRK current (IDA(GIRK)), thereby activating VTA dopamine neurons, with an IC50 of 7.0 μM for IDA(GIRK). Tipepidine activates AMPK. Tipepidine citrate has antidepressant-like effects. Tipepidine citrate enhances the analgesic effect of Carbamazepine (HY-B0246). Tipepidine citrate improves adipose tissue fibrosis and glucose intolerance in high-fat diet-induced obese mice[1][2][3][4].
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