Moxilubant
CAS No. : 146978-48-5
(Synonyms: CGS 25019C (free base))
| Size | Price | Stock |
|---|---|---|
| 5mg | $495 | In-stock |
| 10mg | $735 | In-stock |
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| Cat. No. : | HY-106929 |
| M.Wt: | 455.59 |
| Formula: | C26H37N3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Moxilubant (CGS 25019C free base) is an orally active BLT1 antagonist. Moxilubant inhibits LTB4 signaling with a potency of 2-4 nM. Moxilubant blocks LTB4-induced neutrophil functions. Moxilubant inhibits ear edema and neutrophil infiltration in mice. Moxilubant can be used in research related to chronic obstructive pulmonary disease[1][2].
In Vivo:Moxilubant (0.1-10 mg/kg; p.o.; single administration) dose-dependently inhibits arachidonic acid (HY-109590)-induced ear edema and neutrophil infiltration in mice[1].
Moxilubant (oral administration; single dose) dose-dependently inhibits LTB4-induced neutropenia in rats, with ED50 values ranging from 2 mg/kg to 11 mg/kg within 1 to 18 hours post-administration[1].
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