FR-146687
CAS No. : 146939-64-2
(Synonyms: FK 687; TF 505)
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| Cat. No. : | HY-19284 |
| M.Wt: | 511.65 |
| Formula: | C33H37NO4 |
| Purity: | >98 % |
| Solubility: |
FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases[1].
IC50 & Target:IC50: 1.7 nM (Rat 5α-reductase) and 4.6 nM (Human 5α-reductase)[1]
In Vivo:FR-146687 (0.032-3.2 mg/kg; po; 2, 7, 14, or 21 days) dose-dependently reduces ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg[1].
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