K-Ras(G12C) inhibitor 12
CAS No. : 1469337-95-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $118 | In-stock |
| 10mg | $177 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $720 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-18707 |
| M.Wt: | 449.67 |
| Formula: | C15H17ClIN3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
K-Ras(G12C) inhibitor 12 is an irreversible inhibitor of K-Ras(G12C). K-Ras(G12C) inhibitor 12 can alter the nucleotide-binding preference of K-Ras and block its interaction with effector proteins. K-Ras(G12C) inhibitor 12 can reduce cell viability and induce apoptosis in lung cancer cell lines with G12C mutations. K-Ras(G12C) inhibitor 12 has anti-tumor activity[1]. In Vitro:K-Ras(G12C) inhibitor 12 (Compound 12) (0.01-10 μM; 48-72 h) can inhibit cell viability and increase apoptosis in lung cancer cell lines with K-Ras (G12C) mutations[1].
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