Thiomarinol A


CAS No. : 146697-04-3

(Synonyms: 4-Hydroxythiomarinol C)

146697-04-3
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Cat. No. : HY-107164
M.Wt: 640.81
Formula: C30H44N2O9S2
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 146697-04-3 :

Thiomarinol A (4-Hydroxythiomarinol C) is a potent antibiotic. Thiomarinol A is a hybrid of dithiolopyrrolone and marinolic acid. Thiomarinol A shows antimicrobial activity. Thiomarinol A inhibits MRSA IleRS in a dose-dependent with a Kiapp value of 19 nM[1]. In Vitro: Thiomarinol A shows antimicrobial activity with MICs of 0.002, 0.08, 0.04, 0.04, 0.50, 0.02, 0.01 µM for COL IleRS, LLMR COL IleRSV588F/V631F, LLMR COL IleRSF587V/V631F, LLMR COL IleRSV588F, IleRSV588F MupA, thiomarinol-resistant COL IleRSG593D, thiomarinol-resistant COL IleRSP606S, respectively[1].

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