SR11237
CAS No. : 146670-40-8
(Synonyms: BMS-649)
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $130 | In-stock |
| 10mg | $235 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $860 | In-stock |
| 100mg | $1200 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-107413 |
| M.Wt: | 380.48 |
| Formula: | C24H28O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C) |
SR11237 (BMS-649) is a potent retinoid X receptor (RXR)-selective agonist that is devoid of any RAR activity. SR11237 can cause RXR/RXR homodimers to form and transactivate a reporter gene containing a RXR-response element[1][2][3]. In Vitro: Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors[1]. In Vivo: SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate[2].
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