(RS)-MCPG
CAS No. : 146669-29-6
(Synonyms: alpha-MCPG)
| Size | Price | Stock |
|---|---|---|
| 1mg | $34 | In-stock |
| 5mg | $58 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $158 | In-stock |
| 50mg | $268 | In-stock |
| 100mg | $456 | In-stock |
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| Cat. No. : | HY-100371 |
| M.Wt: | 209.20 |
| Formula: | C10H11NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 6 mg/mL (ultrasonic;warming);H2O : < 0.1 mg/mL (ultrasonic;heat to 80°C);1M NaOH : 100 mg/mL (ultrasonic;adjust pH to 10 with NaOH) |
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].
IC50 & Target: group I/group II mGluR[1]
In Vitro: MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)[2].
In Vivo: (RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[1].
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].
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