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|---|---|---|
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| Cat. No. : | HY-109075 |
| M.Wt: | 232.28 |
| Formula: | C13H16N2O2 |
| Purity: | >98 % |
| Solubility: |
Tasipimidine is an orally active and selective α2A-adrenoceptor agonist with a pEC50 of 7.57 for human α2A-adrenoceptors and an EC50 of 5.7 nM for rat α2-adrenoceptor. Tasipimidine can be utilized in research related to situational anxiety and fear[1][2].
In Vivo:Tasipimidine (10-3000 μg/kg; subcutaneous injection/oral administration; single dose) reduces spontaneous locomotor activity in mice[1].
Tasipimidine (300-1000 μg/kg; subcutaneous injection; single dose) reduces the amplitude of the acoustic startle reflex in rats, with onset within 20 minutes, peak effect at 1 hour, and duration of at least 2 hours[1].
Tasipimidine (10-30 μg/kg; oral administration; total 3 treatment cycles) has an improving effect on separation anxiety in dogs[2].
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