FR901464
CAS No. : 146478-72-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $400 | In-stock |
| 5mg | $710 | In-stock |
| 10mg | $1000 | In-stock |
| 25mg | $1780 | In-stock |
| 50mg | $2860 | In-stock |
| 100mg | $4580 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16212 |
| M.Wt: | 507.62 |
| Formula: | C27H41NO8 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1]. In Vitro: FR901464 (10-20 ng/ml; 6-24 hours) inhibits the growth of murine solid tumors, Colon 38 carcinoma and Meth A fibrosarcoma. FR901464 induces characteristic G1 and G2/M phase arrest in the cell cycle and internucleosomal degradation of genomic DNA with the same kinetics as activation of SV40 promoter-dependent cellular transcription in M-8 tumor cells[1].FR901464 (1-10 ng/ml; 16 hours) suppresses the transcription of some inducible endogenous genes but not house keeping genes in M-8 cells[1].FR901464 exhibits potent anticancer activity. It shows enhancement of activity of a promoter of the SV40 DNA tumor virus at 10 nM concentration in M-8 cells[1].
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