NCGC 607
CAS No. : 1462267-07-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $270 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-120034 |
| M.Wt: | 543.35 |
| Formula: | C24H22IN3O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
NCGC 607 is a noninhibitory small-molecule chaperone of glucocerebrosidase (GCase). NCGC 607 can increase GCase activity, reduce α-synuclein levels, and decrease glycolipid levels. NCGC 607 can be used in the research of Gaucher disease and Parkinson's disease[1].
In Vitro:NCGC 607 (3 μM; 6 d) increases GCase activity, elevates GCase protein levels, and reduces glucosylceramide storage in macrophages[1].
NCGC 607 (3 μM; 21 d) decreases α-synuclein levels and reduces its colocalization with the lysosomal marker Lamp2 in dopaminergic neurons[1].
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