MSC2504877
CAS No. : 1460286-21-8
(Synonyms: M2912)
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $410 | In-stock |
| 50mg | $570 | In-stock |
| 100mg | $800 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123851 |
| M.Wt: | 282.34 |
| Formula: | C17H18N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
MSC2504877 (M2912) is a potent and orally active tankyrase inhibitor with IC50s of 0.0007, 0.0008, 0.54 µM for TNKS, TNKS2, PARP1, respectively. MSC2504877 increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels. MSC2504877 shows anti-tumor activity[1].
In Vitro:MSC2504877 (1, 3, 10 µM; 24 h) increases the expression of AXIN2 and TNKS protein levels and decreases β-catenin levels in APC mutant COLO320DM colorectal tumor cells[1].
MSC2504877 (0-100 µM; 5 days) inhibits the survival of APC−/− cells and COLO320DM cells[1].
MSC2504877 (1 µM; 24 h) combinant with albociclib (HY-50767) (0.03 µM) induces cell cycle arrest at G1 phase[1].
In Vivo:MSC2504877 (30 mg/kg; p.o.; once) inhibits TNKS and Wnt signalling in mice[1].
MSC2504877 (30 mg/kg+ palbociclib (HY-50767) 150 mg/kg; p.o.; once) suppresses hyperproliferation in Apc defective cells in vivo[1].
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