Adenosine N1-oxide
CAS No. : 146-92-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $141 | In-stock |
| 5mg | $274 | In-stock |
| 10mg | $418 | In-stock |
| 25mg | $751 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-102082 |
| M.Wt: | 283.24 |
| Formula: | C10H13N5O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Adenosine N1-oxide is an oral active anti-inflammatory agent, and can be isolated from royal jelly. Adenosine N1-oxide promotes osteogenic and adipocyte differentiation[1][2].
In Vitro: Adenosine N1-oxide )(1-40 μM, 24 h) inhibits TNF-α and IL-6 secretion by RAW264.7 cells stimulated with 2 µg/mL LPS (HY-D1056)[2].
Adenosine N1-oxide )(20/100 μM, 30 mins) increases intracellular cAMP production in both peritoneal macrophages and RAW264.7 cells in a dose-dependent manner[2].
Adenosine N1-oxide )(5-10 μM, 30 mins) increases the protein level of phosphorylation of Akt and GSK-3β in 2 µg/mL LPS (HY-D1056)-stimulated RAW264.7 cells[2].
Adenosine N1-oxide )(2-10 μM, 6-7 days) promotes osteogenic and adipocyte differentiation in MC3T3-E1 cells[2].
In Vivo: Adenosine N1-oxide (oral administration, 135 mg/kg for three times) reduces the lethality caused by LPS (HY-D1056)-induced endotoxin shock in BALB/c mice[1].
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