Guanosine 5'-diphosphate

Guanosine 5'-diphosphate (GDP) is a nucleoside diphosphate that activates adenosine 5'-triphosphate-sensitive K⁺ channel. Guanosine 5'-diphosphate is an iron mobilizer, which forms a complex with hepcidin to inhibit the hepcidin-ferroportin (FPN) interaction and modulates the IL-6/stat-3 pathway. Guanosine 5'-diphosphate ameliorates the Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO₄. Guanosine 5'-diphosphate can be used in the research of AI^[1][2]. IC50 & Target:K+ channel^[1], endogenous metabolite^[2]. In Vitro:Guanosine 5'-diphosphate (100 μM-1 mM) can activate the ATP-sensitive K⁺ channel in the rabbit portal vein, in the presence of Pinacidil (HY-14290)^[1].
Guanosine 5'-diphosphate (10 μM, 24 h) inhibits hepcidin-induced FPN internalization in FPN-GFP cell lines (HEK293T) and antagonizes hepcidin to increase the FPN-mediated cellular iron efflux in HepG2 and Caco-2 cells^[2]. In Vivo:Guanosine 5'-diphosphate (30 mg/kg, i.p., sigle dose) increases iron absorption in normal BALB/c mice when combined with iron supplement FeSO₄ (2 mg/kg)^[2].
Guanosine 5'-diphosphate (30 mg/kg, i.p., every 24 hours for 2 weeks) ameliorates the Turpentine-induced AI in mice when combined with FeSO₄ (2 mg/kg)^[2].