Fluphenazine (dihydrochloride)
CAS No. : 146-56-5
| Size | Price | Stock |
|---|---|---|
| 100mg | $79 | In-stock |
| 500mg | $150 | In-stock |
| 1g | $190 | In-stock |
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| Cat. No. : | HY-A0081 |
| M.Wt: | 510.44 |
| Formula: | C22H28Cl2F3N3OS |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 38 mg/mL;H2O : 100 mg/mL (ultrasonic) |
Fluphenazine dihydrochloride is a potent, orally active phenothiazine-based dopamine receptor antagonist. Fluphenazine dihydrochloride blocks neuronal voltage-gated sodium channels. Fluphenazine dihydrochloride acts primarily through antagonism of postsynaptic dopamine-2 receptors in mesolimbic, nigrostriatal, and tuberoinfundibular neural pathways. Fluphenazine dihydrochloride can antagonize Methylphenidate-induced stereotyped gnawing and inhibit climbing behaviour in mice. Fluphenazine dihydrochloride can be used for researching psychosis and painful peripheral neuropathy associated with diabetes and has potential to inhibit SARS-CoV-2[1][2][3][4][6].
In Vivo:Fluphenazine (1 mg/kg; IG, treated from day 6 to day 15 of gestation) dihydrochloride causes malformations in pregnant mice[5].
Fluphenazine (0.125-1 mg/kg; IP, single dosage) dihydrochloride antagonizes Methylphenidate-induced stereotyped gnawing; inhibits significantly climbing behaviour[6].
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