OPC-14523 (free base)
CAS No. : 145969-30-8
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| Cat. No. : | HY-116594 |
| M.Wt: | 413.94 |
| Formula: | C23H28ClN3O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
OPC-14523 free base is an orally active sigma and 5-HT1A receptor agonist, with high affinity for sigma receptors (σ1/2 IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM). OPC-14523 free base shows antidepressant-like activity[1][2]. In Vivo: OPC-14523 free base (0.3-100 mg/kg; p.o.; daily for 0, 2, 4, 7 days) produces a marked antidepressant-like effect in the forced swimming test (FST) with rats and mice without affecting the general locomotor activity[1].
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