CPS-11
CAS No. : 145945-21-7
(Synonyms: N-(Hydroxymethyl)thalidomide)
| Size | Price | Stock |
|---|---|---|
| 1mg | $500 | In-stock |
| 5mg | $1077 | In-stock |
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| Cat. No. : | HY-117987 |
| M.Wt: | 288.26 |
| Formula: | C14H12N2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 57.7 mg/mL (ultrasonic;warming) |
CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines[1][2][3].
In Vitro: CPS-11 abrogates ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells, confirming its ability to target tumor cells in the bone marrow microenvironment[1].
CPS-11 (0-200 μM, 0 or 4 h) shows virtually no effect on activation of p38 and only slight, transient activation of ATF2 and HSP27[2].
CPS-11 (0-100 μM, 24 or 48 h) was no toxic to H157 cells, WT MEFs or the p38α-/- MEFs at doses as high as 100 μM[2].
CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2].
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