Liarozole (hydrochloride)
CAS No. : 145858-50-0
(Synonyms: R75251 (hydrochloride))
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| Cat. No. : | HY-106019A |
| M.Wt: | 345.23 |
| Formula: | C17H14Cl2N4 |
| Purity: | >98 % |
| Solubility: |
Liarozole hydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole hydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of retinoic acid (IC50=7 μM), resulting in increased tissue levels of retinoic acid. Liarozole hydrochloride shows antitumoral properties[1][2][3].
IC50 & Target:IC50: 7 μM (P450)[1]
In Vitro:Liarozole (0.01~10 μM; 9 days; MCF-7 cells) inhibits cells proliferation[3].
Liarozole (1 μM; 4 days; mesenchymal cells) completely inhibits chondrogenesis[4].
In Vivo:Liarozole (5-20 mg/kg; p.o.; 3 days) reverses the vaginal keratosis caused by estrogen stimulation[5].
Liarozole (40 mg/kg; p.o.; 21 days) reduces tumor burden substantially[6].
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