Margatoxin


CAS No. : 145808-47-5

145808-47-5
Price and Availability of CAS No. : 145808-47-5
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Cat. No. : HY-P1280
M.Wt: 4178.95
Formula: C178H286N52O50S7
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 145808-47-5 :

Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (Kd=11.7 pM). Margatoxin inhibits the Kv1.2 (Kd=6.4 pM) and Kv1.1 (Kd=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research[1][2]. IC50 & Target:Kd: 11.7 pM (Kv1.3), 6.4 pM (Kv1.2) and 4.2 nM (Kv1.1)[1] In Vivo: Margatoxin (i.p.; 1 pmol/g) significantly decreases thiogycollate-induced leukocyte transmigration in the peritoneal cavity in 12-week-old C57BL6/J mice[2].

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