Goserelin (acetate)


CAS No. : 145781-92-6

(Synonyms: ICI-118630 (acetate))

145781-92-6
Price and Availability of CAS No. : 145781-92-6
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10mg $132 In-stock
50mg $396 In-stock
100mg $640 In-stock
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Cat. No. : HY-13673A
M.Wt: 1000.00
Formula: C59H84N18O14·xC2H4O2
Purity: >98 %
Solubility: DMSO : ≥ 28 mg/mL;H2O : 100 mg/mL (ultrasonic)
Introduction of 145781-92-6 :

Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2]. IC50 & Target:GnRH[1] In Vitro: Goserelin (1 nM-1 mM; 48-72 hours) promotes EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) promotes EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].
In Vivo: Goserelin (100 μg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

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