JG-98
CAS No. : 1456551-16-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $70 | In-stock |
| 5mg | $162 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $447 | In-stock |
| 50mg | $710 | In-stock |
| 100mg | $995 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117282 |
| M.Wt: | 534.54 |
| Formula: | C24H21Cl2N3OS3 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[1][2][3].
IC50 & Target: Heat shock protein 70[1]
In Vitro: JG-98 (30 nM-30 μM; 72 hours) has antiproliferative activity across a range of cell lines with the EC50s between ~0.3 and 4 μM[2].
JG-98 (10 μM; 48 hours) activates apoptotic mediators (cleavage of caspase-3 and PARP) in MDA-MB-231 cells[1].
JG-98 destabilizes FoxM1 and relieves suppression of downstream effectors, including p21 and p27[2].
In Vivo: JG-98 (3 mg/kg; i.p.; on days 0, 2, and 4) suppresses tumor growth in xenograft models bearing MCF7 and HeLa cells[2].
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