Cyclocommunol
CAS No. : 145643-96-5
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| Cat. No. : | HY-N3665 |
| M.Wt: | 352.34 |
| Formula: | C20H16O6 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Cyclocommunol is a GST inhibitor with an IC50 of 3.0 μM. Cyclocommunol downregulates the expression of the anti-apoptotic (apoptosis) protein Mcl-1, reduces the levels of phosphorylated Akt and mTOR, and induces caspase-dependent apoptosis, reactive oxygen species (ROS) production and autophagy. Cyclocommunol can be used in research related to oral squamous cell carcinoma, breast cancer, lung cancer, norovirus-induced gastroenteritis and bacterial infections[1][2][3][4][5].
In Vitro:Cyclocommunol (CYC) (1-5 μM; 24-48 h) potently inhibits the viability of human oral squamous cell carcinoma cell lines SCC2095 and Ca922, with IC50 values of 4.2 μM and 5.0 μM respectively after 48 h of incubation[1].
Cyclocommunol (compound 1) at concentrations greater than 100 μM shows no detectable cytotoxicity against MCF-7 human breast cancer cells or NCI-H460 human lung cancer cells[5].
Cyclocommunol (1-5 μM; 48 h) induces concentration-dependent apoptosis in human oral squamous cell carcinoma cell line SCC2095[1].
Cyclocommunol (1-5 μM; 48 h) activates caspase-dependent apoptosis, induces DNA damage, downregulates the Akt/mTOR pathway in human oral squamous cell carcinoma cell lines SCC2095 and Ca922 after 48 h of incubation, and regulates the expression of pro-apoptotic and anti-apoptotic proteins in SCC2095 cells[1].
Cyclocommunol (3 μM; 12-48 h) exhibits pro-apoptotic activity that is partially dependent on Mcl-1[1].
Cyclocommunol (3 μM; 3 h) induces reactive oxygen species production in the human oral squamous cell carcinoma cell line SCC2095[1].
Cyclocommunol (2-5 μM; 48 h) induces autophagy in the human oral squamous cell carcinoma cell line SCC2095[1].
Cyclocommunol (compound 5) at 100 μM weakly inhibits 15-LOX activity[2].
Cyclocommunol (compound 8) potently inhibits GST activity in cell-free biochemical assays, with an IC50 value of 3.0 μM[3].
Cyclocommunol exhibits weak antibacterial activity against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica in agar diffusion assays[5].
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