PU-WS13
CAS No. : 1454619-14-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $108 | In-stock |
| 10mg | $156 | In-stock |
| 25mg | $360 | In-stock |
| 50mg | $672 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-18680 |
| M.Wt: | 411.35 |
| Formula: | C17H20Cl2N6S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 40 mg/mL |
PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM. IC50 & Target:EC50: 0.22 μM (Grp94), 7.3 μM (Trap-1), 27.3 μM (Hsp90α), 41.8 μM (Hsp90β)[1] In Vitro: PU-WS13 is a Grp94 inhibitor, with an EC50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC50s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells[1].
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