Mitiglinide
CAS No. : 145375-43-5
(Synonyms: KAD-1229 (free acid anhydrous); S21403 (free acid anhydrous))
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| Cat. No. : | HY-B0682 |
| M.Wt: | 315.41 |
| Formula: | C19H25NO3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Mitiglinide (KAD-1229), an insulinotropic agent, is an ATP-sensitive K+ (KATP) channel antagonist. Mitiglinide is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide can be used for the research of type 2 diabetes[1][2].
IC50 & Target: KATP channel[1]
In Vitro: Mitiglinide inhibits the Kir6.2/SUR1 channel currents in a dose-dependent manner (IC50 of 100 nM) but does not significantly inhibit either Kir6.2/SUR2A or Kir6.2/SUR2B channel currents even at high doses (more than 10 μM) in COS-1 cells[1].
In Vivo: Mitiglinide (1-3 mg/kg; p.o.) suppresses the increase in plasma glucose levels seen after a meal load and the area under the curve for plasma glucose levels (AUCglucose) up to 5 h after the meal load[2].
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