BI 186908
CAS No. : 1453500-36-1
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| Cat. No. : | HY-120847 |
| M.Wt: | 422.48 |
| Formula: | C23H26N4O4 |
| Purity: | >98 % |
| Solubility: |
BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity[1].
In Vivo:IC50: 22 nM (MCH receptor 1)
Ki: 14 nM (MCH receptor 1)
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