ASP5878
CAS No. : 1453208-66-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $75 | In-stock |
| 5mg | $200 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $540 | In-stock |
| 50mg | $756 | In-stock |
| 100mg | $1058 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19983 |
| M.Wt: | 407.37 |
| Formula: | C18H19F2N5O4 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 250 mg/mL |
ASP5878 is an oral active inhibitor of FGFR 1, 2, 3, and 4, with IC50 values of 0.47 nM, 0.6 nM, 0.74 nM and 3.5 nM for FGFR 1, 2, 3, and 4 kinase activity. ASP5878 has potential antineoplastic activity[1].
IC50 & Target: IC50: 0.47 nM/0.6 nM/0.74 nM/3.5 nM (FGFR1/2/3/4)[1].
In Vitro: ASP5878 shows potent antiproliferative activity in most human HCC cell lines[1].
ASP5878 inhibits FGFR4 phosphorylation in a concentration-dependent manner. ASP5878 treatment results in the suppression of phosphorylation, mobility shift of FRS2, and suppression of ERK phosphorylation[1].
In Vivo: ASP5878 (3 mg/kg, orally, once daily) shows antitumor activity in a Hep3B2.1-7 subcutaneous xenograft and HCC orthotopic xenograft mouse model[1].
ASP5878 induces shrinkage of FGF19-expressing HCC xenograft model[1].
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