Bisindolylmaleimide X (hydrochloride)
CAS No. : 145317-11-9
(Synonyms: BIM-X (hydrochloride); Ro31-8425 (hydrochloride))
| Size | Price | Stock |
|---|---|---|
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| 10mg | $275 | In-stock |
| 50mg | $825 | In-stock |
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| Cat. No. : | HY-108136A |
| M.Wt: | 460.96 |
| Formula: | C26H25ClN4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 20.83 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) |
Bisindolylmaleimide X hydrochloride(Ro 31-8425 hydrochloride, BIM-X hydrochloride) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X hydrochloride is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X hydrochloride inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X hydrochloride inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X hydrochloride can be used for research on the immune system and cardiovascular diseases[1][2][3]. In Vitro:Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride; Ro31-8425 hydrochloride) derivatives acts as an useful tool to compare inhibitor potencies and selectivities for a target of interest[1].
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