KDM2/7-IN-1
CAS No. : 1453071-47-0
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|---|---|---|
| 1mg | $76 | In-stock |
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| Cat. No. : | HY-107573 |
| M.Wt: | 285.38 |
| Formula: | C15H27NO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 30 mg/mL (ultrasonic) |
KDM2/7-IN-1 (TC-E 5002) is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 values are 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A respectively). KDM2/7-IN-1 inhibits growth of HeLa and KYSE-150 cancer cells in vitro[1]. In Vitro:KDM2/7-IN-1 (50 μM, 24 hours) significantly increases H3K27me2 levels in N2a cells[1]. KDM2/7-IN-1 (GI50: 40 μM, 16 μM, 48 hours) significantly inhibits the proliferation of HeLa and KYSE150 cells[1].
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