Picolinamide
CAS No. : 1452-77-3
(Synonyms: 2-Picolinamide)
| Size | Price | Stock |
|---|---|---|
| 5g | $8 | In-stock |
| 10g | $12 | In-stock |
| 25g | $15 | In-stock |
| 100g | $43 | In-stock |
| 500g | $181 | In-stock |
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| Cat. No. : | HY-101020 |
| M.Wt: | 122.13 |
| Formula: | C6H6N2O |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : 50 mg/mL (ultrasonic) |
Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3]. IC50 & Target:Poly(ADP-ribose) synthetase[1] In Vitro: Picolinamide (10 μM-1 mM) inhibits Poly(ADP-ribose) synthetase activity[2]. Picolinamide (2 mM) protects against streptozotocin-induced depression of proinsulin synthesis in isolated pancreatic islets of rats[3]. In Vivo: Picolinamide (4 mmol/kg, i.p., rats) inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles[1]. Picolinamide (250 mg/kg, i.p., rats) enhances the tumorigenic effect of Streptozotocin and Alloxan on islet B-cells[4].
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