VU0467154
CAS No. : 1451993-15-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $121 | In-stock |
| 10mg | $165 | In-stock |
| 25mg | $319 | In-stock |
| 50mg | $539 | In-stock |
| 100mg | $935 | In-stock |
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| Cat. No. : | HY-112209 |
| M.Wt: | 444.45 |
| Formula: | C17H15F3N4O3S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 13.89 mg/mL (ultrasonic) |
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively. IC50 & Target: pEC50: of 7.75 (Rat M4 receptor), 6.2 (Human M4 receptor), 6 (Cynomolgus monkey M4 receptor)[1] In Vitro: VU0467154 is a positive allosteric modulators of the M4 muscarinic acetylcholine receptor (mAChR), robustly potentiates the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey (cyno) M4 receptor, respectively. VU0467154 does not potentiate the ACh response at rat and human M1, M2, M3, or M5[1]. In Vivo: VU0467154 (1-56.6 mg/kg, p.o. or i.p.) reverses amphetamine-induced hyperlocomotion in rats. VU0467154 (0.3-30 mg/kg, i.p.) reverses amphetamine- and MK-801-induced hyperlocomotion in wild-type but not M4 KO mice. VU0467154 alone also enhances the acquisition of both contextual and cue-mediated fear conditioning in wild-type mice[1].
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