Kaliotoxin
CAS No. : 145199-73-1
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| Cat. No. : | HY-P1281 |
| M.Wt: | 4149.94 |
| Formula: | C171H283N55O49S8 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Kaliotoxin is a peptidyl inhibitor of neuronal BK-Type. Kaliotoxin can specific inhibit Kv channels and calcium-activated potassium channels. Kaliotoxin can be used for the research of the regulation of membrane potential and neuron excitability[1][2].
IC50 & Target:Kd: 20 nM (KCa channel)[1]
In Vitro: Kaliotoxin (KTX) (250 nM) specifically suppressed the whole cell Ca2+-activated K+ current[1].
Kaliotoxin interacts in a one-to-one way with KCa channels with a Kd of 20 nM[1].
In Vivo: Kaliotoxin facilitates cognitive processes by the blockage of Kv1.1 or Kv1.3 channels[2].
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