Iodophenpropit (dihydrobromide)
CAS No. : 145196-87-8
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| Cat. No. : | HY-107568 |
| M.Wt: | 576.13 |
| Formula: | C15H21Br2IN4S |
| Purity: | >98 % |
| Solubility: | DMSO : 57.6 mg/mL (ultrasonic;warming) |
Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM)[1].
In Vitro: Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor[2].
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC50 of 1.57±0.3 μM[3].
In Vivo: Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits[4].
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