CP-99994 (hydrochloride)


CAS No. : 145148-39-6

145148-39-6
Price and Availability of CAS No. : 145148-39-6
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Cat. No. : HY-12145
M.Wt: 369.33
Formula: C19H26Cl2N2O
Purity: >98 %
Solubility:
Introduction of 145148-39-6 :

CP-99994 hydrochloride is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 hydrochloride prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].

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