SBI-425
CAS No. : 1451272-71-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $90 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $480 | In-stock |
| 100mg | $770 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-124756 |
| M.Wt: | 341.77 |
| Formula: | C13H12ClN3O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 86.67 mg/mL (ultrasonic) |
SBI-425 is an orally active and potent TNAP (tissue-nonspecific alkaline phosphatase) inhibitor (IC50=16 nM). SBI-425 inhibits TNAP in the vasculature, improving cardiovascular parameters and survival[1][2]. IC50 & Target:IC50: 16 nM (TNAP)[1] In Vitro:SBI-425 treatment suppresses Foxp3 expression in CD4+ and CD8+ T cells in splenocytes from CLP-injured mice[3]. In Vivo:
| Compds | SBI-425 |
| Clp (mL/min/kg) | 5.14 |
| Vd (L/kg) | 1.03 |
| Cmax (μg/mL) | 178 |
| AUC (μg*hr/mL) | 848 |
| t1/2 (hr) | 2.3 |
| %F | 58 |
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Inquiry Information- Product Name:
- SBI-425
- Cat. No.:
- HY-124756
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