KAN0438757
CAS No. : 1451255-59-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $130 | In-stock |
| 5mg | $275 | In-stock |
| 10mg | $440 | In-stock |
| 25mg | $770 | In-stock |
| 50mg | $1089 | In-stock |
| 100mg | $1520 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-112808 |
| M.Wt: | 447.43 |
| Formula: | C21H18FNO7S |
| Purity: | >98 % |
| Solubility: | DMSO : 130 mg/mL (ultrasonic) |
KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM[1].
IC50 & Target:IC50: 0.19 μM (PFKFB3)[1]
In Vitro:KAN0438757 (72 h) inhibits cell viability of Miapaca-2, PANC1, SW620, U-266, AMO-1 (IC50: 2.75, 3.83, 7.50, 5.08, 11.53 μM respectively)[1].
KAN0438757 (10 μM, 6 h) decreases homologous recombination (HR) activity and increases ionizing radiation (IR) induced γH2AX foci level in U2OS cells[1].
KAN0438757 (50 μM, 12 h) reduces PFKFB3 protein expression in HCT-116, SW-1463 and HUVECs[2].
KAN0438757 (0-50 μM, 24 h) reduces glycolysis in HCT-116 cancer cells and HUVECs[2].
In Vivo:KAN0438757 (i.p., 10; 25; 50 mg/kg) is well tolerated, and shows no relevant systemic toxic effects in C57BL6/N mice[2].
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