OHM1
CAS No. : 1450995-09-1
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| Cat. No. : | HY-124722 |
| M.Wt: | 494.63 |
| Formula: | C24H42N6O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
OHM1 is an analog of HIF1α CTAD that inhibits its binding with p300/CBP. OHM1 targets CH1 domain with an affinity of 0.53 μM[1].
In Vitro:OHM1 (1-20 μM; 24 h) results in a dose-dependent reduction in the HIF promoter activity, and reduces the level of HIF1α transcriptional activity under hypoxia to that observed under normoxia at 20 μM in MDA-MB-231 cells[1].
OHM1 down-regulates hypoxia-inducible gene expression[1].
OHM1 (10 μM) down-regulates multiple genes implicated in angiogenesis, apoptosis, cell proliferation, and invasion, along with several cancer-specific markers in the A549 non-small-cell lung cancer cell line[1].
In Vivo:OHM1 (15 mg/kg; i.p.; every other day for 15 injections) reduces MDA-MB-231 tumor volume in mice[1].
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