NU9056
CAS No. : 1450644-28-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $90 | In-stock |
| 5mg | $195 | In-stock |
| 10mg | $300 | In-stock |
| 25mg | $495 | In-stock |
| 50mg | $730 | In-stock |
| 100mg | $970 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-110127 |
| M.Wt: | 232.37 |
| Formula: | C6H4N2S4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an [1][2] of 2 µM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells[1].
In Vitro: NU9056 (17-36 µM; 24-96 hours) results in both caspase 3 and caspase 9 activation in a time- and concentration-dependent manner[1].
NU9056 (2.5-40 µM; 2 hours) treatment results in decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation[1].
NU9056 treatment also decreases androgen receptor, prostate specific antigen, p53 and p21 protein levels[1].
In Vivo: The mice are injected with Nu9056 (2 μg/g) and the hippocampus is collected 1 h later. Tip60 inhibition reduces H2A.Z binding at the -1 nucleosome of Arc, and the +1 nucleosome of Arc and Syp. Additionally, Nu9056 increases acetylation at the -1 nucleosome of Fos, Tacstd2, and Gria4, and the +1 nucleosome of Gria4[2].
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