Candesartan Cilexetil
CAS No. : 145040-37-5
(Synonyms: TCV-116)
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| 1g | $92 | In-stock |
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| Cat. No. : | HY-17505 |
| M.Wt: | 610.66 |
| Formula: | C33H34N6O6 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL |
Candesartan Cilexetil (TCV-116) is an angiotensin II receptor inhibitor. Candesartan Cilexetil ameliorates the pulmonary fibrosis and has antiviral and skin wound healing effect. Candesartan Cilexetil can be used for the research of high blood pressure[1][2][3][4][5][6].
In Vitro:Candesartan Cilexetil (0.1-10 μM, 24 h) exhibits antiviral effects against ZIKV in HUVEC cells, HEK293T cells[1].
In Vivo:Candesartan Cilexetil (5 mg/kg, Oral gavage, once a day for 7 weeks) ameliorates myocardial remodeling and heart failure in Dahl salt-sensitive (DS) rats fed a high-salt diet[2].
Candesartan Cilexetil (1-10 mg/kg, Oral, once a day for 15 days) has an effect of skin wound healing in rats[3].
Candesartan Cilexetil (1-10 mg/kg, Administered through a stomach tube, once a day for 4-12 weeks) inhibits the increase in blood pressure in spontaneously hypertensive rats[5].
Candesartan Cilexetil (10 mg/kg, Oral, supplemented in drinking water, for 2-23 days) inhibits the synthesis of TGF-b1 and ameliorates the pulmonary fibrosis in bleomycin (HY-108345) induced pulmonary fibrosis model rats[6].
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