Fmoc-Glu-OMe

Fmoc-Glu-OMe is a glutamic acid derivative. Fmoc-Glu-OMe exhibits significant antibacterial activity and excellent gelation properties in silver nitrate (AgNO₃) solution. Fmoc-Glu-OMe promotes wound healing in rat models and eliminates bacteria in MRSA-infected rat wound models. Fmoc-Glu-OMe can be used in studies related to wound infections and MRSA-infected wounds^[1][2]. IC50 & Target:Bacteria^[1] In Vitro:Fmoc-Glu-OMe hydrogel exhibits measurable antibacterial activity against E. coli^[1].
Fmoc-Glu-OMe hydrogel (FHAg-15) (FHAg-15 hydrogel at pH 6.0; 16 h) exhibits potent broad-spectrum antibacterial activity against E. coli, S. aureus, P. aeruginosa, and methicillin-resistant S. aureus (MRSA) in vitro, as determined by the disk diffusion assay^[2].
Fmoc-Glu-OMe hydrogel (FHAg-15) (FHAg-15 hydrogel; 24 h) potently inhibits biofilm formation of Staphylococcus aureus (to 7.6% of the control level) and Escherichia coli (to 29.8% of the control level) in vitro^[2].
Fmoc-Glu-OMe hydrogel (FHAg-15) (pH 4.0-7.4; 24 h; 48 h) significantly promotes NIH-3 T3 cell migration and in vitro wound healing under pH 6.0 and 7.4 conditions^[2]. In Vivo:Fmoc-Glu-OMe hydrogel (FHAg-10/15) (500 μL; topical administration) achieves a wound healing rate of 93.01% within 12 days; in a rat MRSA-infected full-thickness wound model, the FHAg-15 hydrogel prepared from Fmoc-Glu-OMe (500 μL; topical administration) achieves an MRSA clearance rate of 99.9% and a wound healing rate of 97.07% within 12 days^[2].