Chlorindanol

Chlorindanol (Clorindanol) is a disinfectant. Chlorindanol inhibits Gram-negative and Gram-positive multiplying bacteria, dermatophytes, fungi, and viral RNA replication/translation. Chlorindanol immobilizes and kills sperm. Chlorindanol is used in the research of flavivirus infection and trichomoniasis^{[1][2][3][4][5]}. In Vitro:Chlorindanol (0.0025-1.0 mg/mL) exhibits broad-spectrum antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria, and fungi, with minimum inhibitory concentrations and bactericidal concentrations typically ranging from 0.0125 to 0.4 mg/mL^[1].
Chlorindanol exhibits amoebicidal activity against Endamoeba histolytica, with dilutions reaching 1:10,000 for trophozoites and 1:2,500 for cysts^[1].
Chlorindanol exhibits rapid bactericidal activity against various bacteria and fungi at room temperature, with killing times ranging from less than 5 minutes to 60 minutes, depending on the microbial species and dilution^[1].
Chlorindanol exhibits trichomonacidal activity, rapidly immobilizing and killing Trichomonas species at dilutions ranging from 1:2,000 to 1:8,000^[1].
Chlorindanol exhibits potent spermicidal activity, immobilizing sperm immediately at dilutions of 1:2,000 and 1:3,000^[1].
Chlorindanol inhibits ZIKV infection in Huh-7.5 cells^[2]. In Vivo:Chlorindanol (48-920 mg/Kg; p.o.; i.v.; i.p.) shows low acute systemic toxicity in mice, with oral LD₅₀ of 920 mg/Kg at 7 days, intravenous LD₅₀ of 48 mg/Kg, and intraperitoneal LD₅₀ of 96 mg/Kg at 7 days^[1].
In a three-week oral toxicity test in rats, chlorindanol (200-800 mg/Kg; p.o.; daily; 21 days) at 200 mg/Kg/day is completely tolerated, while 400 and 800 mg/Kg/day cause dose-related retardation of weight gain without deaths^[1].