Dehydrocholic acid (sodium)

Dehydrocholate sodium is an orally active hydrocholeretic agent. Dehydrocholate sodium modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholate sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholate sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice^{[1][2][3][4][5]}. In Vitro: Dehydrocholate sodium (Dehydrocholic acid; 50-200 μM; 50 min) reduces the necrosis of pancreatic acinar cells induced by sodium Taurocholate (HY-N0545)^[1].
In Vivo: Dehydrocholate sodium (Dehydrocholic acid; 25-50 mg/kg; i.p.; 1, 3 and 6 h after the surgery for 3 times) alleviates the severity of Sodium taurocholate-induced acute biliary pancreatitis in C57BL/6 mice, reducing pancreatic histopathological alterations, serum amylase and lipase levels, and suppressing pancreatic trypsin and MPO activities^[1].
Dehydrocholate sodium (1-4 μmol/min/100g BW; intravenous infusion) increases bile flow and reduces the secretion of endogenous and exogenous biliary bile acids and biliary lipids in rats^[2].
Dehydrocholate sodium (Dehydrocholic acid; 100 mg/kg; p.o. via water bottles) shows choleretic and mild hepatoprotective effects in albino rats with obstructive jaundice^[3].
Dehydrocholate sodium (0.4% in diet; p.o.; 1 week) increases liver cholesterol level, bile flow and biliary lipid secretion in rats, and its biological effect is similar to that of cholate^[4].
Dehydrocholate sodium (50 mg/kg initial dose, then 167 mg/kg/hr infusion; i.v. and infusion) increases bile flow but does not affect the biliary excretion of methylmercury in rats^[5].