AZ82
CAS No. : 1449578-65-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
| 25mg | $520 | In-stock |
| 50mg | $830 | In-stock |
| 100mg | $1320 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-12241 |
| M.Wt: | 560.63 |
| Formula: | C28H31F3N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1.
IC50 & Target: IC50: 300nM(KIFC1) [1][2].
Ki: 43 nM (KIFC1)[1][2].
In Vitro: AZ82 is shown to specifically induce multipolar spindles in BT-549 cells, but not in cancer cells with normal centrosome number, such as HeLa[1]. AZ82 binds specifically to KIFC1/MT complex but not to KIFC1 or MT alone. Treatment with AZ82 caused centrosome declustering in BT-549 breast cancer cells with amplified centrosomes. AZ82 inhibits both processes with an IC50 of 0.90 ± 0.09 μM for mant-ATP binding and 1.26 ± 0.51 μM for mant-ADP releasing[2].
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