Size | Price | Stock |
---|---|---|
1mg | $80 | In-stock |
5mg | $120 | In-stock |
10mg | $180 | In-stock |
50mg | $450 | In-stock |
100mg | $750 | In-stock |
200 mg | Get quote | |
500 mg | Get quote | |
We match the lowest price on market. |
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Cat. No. : | HY-100343 |
M.Wt: | 405.42 |
Formula: | C22H20FN5O2 |
Purity: | >98 % |
Solubility: | DMSO : 2.17 mg/mL (5.35 mM; Need ultrasonic) |
GNE-495 is a potent and selective MAP4K4 inhibitor with an IC50 of 3.7 nM. IC50 & Target: IC50: 3.7 nM (MAP4K4)[1] In Vitro: GNE-495 is a potent and selective MAP4K4 inhibitor with efficacy in retinal angiogenesis. GNE-495 shows the best balance of MAP4K4 inhibition, permeability, microsomal stability, and cellular potency[1]. In Vivo: GNE-495 is administered intraperitoneally to neonatal mouse pups at high doses: 25 and 50 mg/kg. GNE-495 shows good in vivo profile in all species tested, with low clearances, moderate terminal half-lives, and reasonable oral exposure levels (F=37-47%)[1].
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