K145 (hydrochloride)
CAS No. : 1449240-68-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $130 | In-stock |
| 25mg | $262 | In-stock |
| 50mg | $393 | In-stock |
| 100mg | $590 | In-stock |
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| Cat. No. : | HY-15779A |
| M.Wt: | 384.92 |
| Formula: | C18H25ClN2O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
K145 hydrochloride is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM. K145 hydrochloride is inactive against SphK1 and other protein kinases. K145 hydrochloride induces cell apoptosis and has potently antitumor activity[1].
IC50 & Target:IC50: 4.3 µM (SphK2)[1]
Ki: 6.4 µM (SphK2)[1]
In Vitro:K145 (0-10 μM; 24-72 hours; U937 cells) treatment significantly inhibits the growth of U937 cells in a concentration-dependent manner[1].
K145 (10 μM; 24 hours; U937 cells) treatment significantly induces apoptosis in U937 cells[1].
K145 (4-8 μM; 3 hours; U937 cells) treatment decreases the phosphorylation of ERK and Akt[1].
Treatment with K145 (10 μM) causes a decrease of total cellular S1P without significant effects on ceramide levels[1].
In Vivo:K145 (50 mg/kg; oral gavage; daily; for 15 days; BALB/c-nu mice) treatment significantly inhibits the growth of U937 tumors in nude mice[1].
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