Azaphilone-9
CAS No. : 1448460-87-4
(Synonyms: AZA-9)
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| Cat. No. : | HY-124844 |
| M.Wt: | 435.31 |
| Formula: | C21H23BrO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression[1]. IC50 & Target:HuR-ARE[1] In Vitro:Azaphilone-9 is a HuR-RNA inhibitor. However HuR binds and stabilizes the AREs of the oncogene Musashi1 (Msi1) and anti-apoptotic proteins, Bcl2 and XIAP, thereby up-regulating their expression and activating the Wnt/Notch signaling pathway and inhibiting apoptosis[1].
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