UAMC-1110
CAS No. : 1448440-52-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $120 | In-stock |
| 10mg | $192 | In-stock |
| 25mg | $355 | In-stock |
| 50mg | $563 | In-stock |
| 100mg | $900 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100684 |
| M.Wt: | 344.32 |
| Formula: | C17H14F2N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
UAMC-1110 is a highly potent and selective inhibitor of fibroblast activation protein (FAP) with an IC50 of 3.2 nM. UAMC-1110 also inhibits prolyl oligopeptidase (PREP) with an IC50 of 1.8 μM[1]. IC50 & Target:IC50: 3.2 nM (FAP), 1.8 μM (PREP)[1] In Vitro:UAMC-1110 is also found to have better FAP/PREP selectivity and a very proficient ligand efficiency of 0.34[1]. In Vivo:UAMC-1110 is the most extensive and prolonged inhibitior of FAP in the PK studies. Pharmacokinetic evaluation in mice of UAMC-1110 demonstrates high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo[1].
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