PAWI-2
CAS No. : 1448427-02-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $325 | In-stock |
| 25mg | $650 | In-stock |
| 50mg | $1040 | In-stock |
| 100mg | $1660 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-123929 |
| M.Wt: | 371.45 |
| Formula: | C19H21N3O3S |
| Purity: | >98 % |
| Solubility: |
PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits β3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis (activation of caspase-3/7), and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin β3 KRAS-dependent human pancreatic cancer stem cells (hPCSCs). PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model[1][2].
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- Cat. No.:
- HY-123929
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