Ivosidenib
CAS No. : 1448347-49-6
(Synonyms: AG-120)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $147 | In-stock |
| 25mg | $240 | In-stock |
| 50mg | $384 | In-stock |
| 100mg | $624 | In-stock |
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| Cat. No. : | HY-18767 |
| M.Wt: | 582.96 |
| Formula: | C28H22ClF3N6O3 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 39 mg/mL |
Ivosidenib (AG-120) is an orally active inhibitor of isocitrate dehydrogenase 1 mutant (mIDH1) enzyme, it exhibits profound d-2-hydroxyglutatrate (2-HG) lowering in vivo. Ivosidenib (AG-120) has the potential for AML therapy due to its acceptable safety profile and clinical activity[1]. IC50 & Target: 12 nM (mouse IDH1R132H)[1] In Vitro: Ivosidenib (AG-120) (0-13 μM; 48 hours) inhibits several IDH1-R132 mutants with potency similar IC50 values: IDH1-R132H (IC50=12 nM); IDH1-R132C (IC50=13 nM); IDH1-R132G (IC50=8 nM); IDH1-R132L (IC50=13 nM); IDH1-R132S (IC50=12 nM), respectively[1]. In Vivo: AG-120 (gavage administration; 50 mg/kg and 150 mg/kg) declines tumor 2-HG concentration rapidly, with maximum inhibition (92.0% and 95.2% at the 50 mg/kg and 150 mg/kg doses, respectively) achieved at -12 h post dose[1].
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