AGI-14100
CAS No. : 1448346-43-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $646 | Get quote |
| 5mg | $1548 | Get quote |
| 10mg | $2142 | Get quote |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-120181 |
| M.Wt: | 599.96 |
| Formula: | C29H22ClF4N5O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC50=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors[1].
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